M A T E R I A L S A F E T Y D A T A S H E E T

Org 27569;5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)ethyl]amide(868273-06-7),SN:OH-028209
Section 1. - - - - - - - - - Chemical Identification- - - - - - - - - -
Product Name:Org 27569;5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)ethyl]amide
CAS:868273-06-7
Product No.:OH-028209

Section 2. - - - - - - - - - Company Identification - - - - - - - - -
Company Name: Yipeng Chemical
Contact Company:www.yipengchem.com

Section 3. - - - - - - - - - - Hazards Identification - - - - - - - - -
Label precautionary statements
Caution:
Toxicity and hazard information unavailable.
Exercise due care.

Section 4. - - - - - - - - - - First-Aid Measures- - - - - - - - - - -
In case of contact, immediately flush eyes with copious amounts of Water for at least 15 minutes.In case of contact, immediately wash skin with soap and copious Amounts of water.If inhaled, remove to fresh air. If not breathing give artificial Respiration. If breathing is difficult, give oxygen.If swallowed, wash out mouth with water provided person is conscious.Call a physician.Wash contaminated clothing before reuse.

Section 5. - - - - - - - - - Fire Fighting Measures - - - - - - - - - -
Extinguishing media Water spray.Carbon dioxide, dry chemical powder or appropriate foam.Special firefighting procedures Wear self-contained breathing apparatus and protective clothing to Prevent contact with skin and eyes.Unusual fire and explosions hazards Emits toxic fumes under fire conditions.

Section 6. - - - - - - - - Accidental Release Measures- - - - - - - - -
Wear respirator, chemical safety goggles, rubber boots and heavy Rubber gloves.Sweep up, place in a bag and hold for waste disposal.Avoid raising dust.Ventilate area and wash spill site after material pickup is complete.

Section 7. - - - - - - - - - - Handling And Storage- - - - - - - - - - -
Refer to section 8.

Section 8. - - - - - - Exposure Controls/Personal Protection- - - - - -
Chemical safety goggles.
Compatible chemical-resistant gloves.
Niosh/msha-approved respirator.
Safety shower and eye bath.
Mechanical exhaust required.
Avoid inhalation.
Avoid contact with eyes, skin and clothing.
Avoid prolonged or repeated exposure.
Keep tightly closed.
Store in a cool dry place.

Section 9. - - - - - - - Physical And Chemical Properties - - - - - - -

Org 27569 is a drug which acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor. Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such as rimonabant. However while Org 27569 increases the ability of CB1 agonists to bind to the receptor, it decreases their efficacy at stimulating second messenger signalling once bound, and so in practice behaves as an insurmountable antagonist of CB1 receptor function

Systematic (IUPAC) name :5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)ethyl]amide

CAS number 868273-06-7

PubChem CID 44828492
ChemSpider 22369629 Y

Formula C24H28ClN3O 
Mol. mass 409.951 g/mol

Section 10. - - - - - - - - -Stability And Reactivity - - - - - - - - -
Incompatibilities Hazardous combustion or decomposition products
Toxic fumes of:

Section 11. - - - - - - - - - Toxicological Information - - - - - - - -
Acute effects May be harmful by inhalation, ingestion, or skin absorption.
May cause eye irritation.
May cause skin irritation.
To the best of our knowledge, the chemical, physical, and Toxicological properties have not been thoroughly investigated.

Section 12. - - - - - - - - - Ecological Information - - - - - - - - - -
N/A

Section 13. - - - - - - - - - Other Information - - - - - - - - -
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